검색결과 : 20건
| No. | Article |
|---|---|
| 1 |
WRN helicase is a synthetic lethal target in microsatellite unstable cancers Chan EM, Shibue T, McFarland JM, Gaeta B, Ghandi M, Dumont N, Gonzalez A, McPartlan JS, Li TX, Zhang YX, Liu JB, Lazaro JB, Gu PL, Piett CG, Apffel A, Ali SO, Deasy R, Keskula P, Ng RWS, Roberts EA, Reznichenko E, Leung L, Alimova M, Schenone M, Islam M, Maruvka YE, Liu Y, Roper J, Raghavan S, Giannakis M, Tseng YY, Nagel ZD, D'Andrea A, Root DE, Boehm JS, Getz G, Chang S, Golub TR, Tsherniak A, Vazquez F, Bass AJ Nature, 568(7753), 551, 2019 |
| 2 |
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies Boettcher S, Miller PG, Sharma R, McConkey M, Leventhal M, Krivtsov AV, Giacomelli AO, Wong WH, Kim J, Chao S, Kurppa KJ, Yang XP, Milenkowic K, Piccioni F, Root DE, Rucker FG, Flamand Y, Neuberg D, Lindsley RC, Janne PA, Hahn WC, Jacks T, Dohner H, Armstrong SA, Ebert BL Science, 365(6453), 599, 2019 |
| 3 |
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells He YJ, Meghani K, Caron MC, Yang CY, Ronato DA, Bian J, Sharma A, Moore J, Niraj J, Detappe A, Doench JG, Legube G, Root DE, D'Andrea AD, Drane P, De S, Konstantinopoulos PA, Masson JY, Chowdhury D Nature, 563(7732), 522, 2018 |
| 4 |
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target Manguso RT, Pope HW, Zimmer MD, Brown FD, Yates KB, Miller BC, Collins NB, Bi K, Lafleur MW, Juneja VR, Weiss SA, Lo J, Fisher DE, Miao D, Van Allen E, Root DE, Sharpe AH, Doench JG, Haining WN Nature, 547(7664), 413, 2017 |
| 5 |
Identification of an oncogenic RAB protein Wheeler DB, Zoncu R, Root DE, Sabatini DM, Sawyers CL Science, 350(6257), 211, 2015 |
| 6 |
A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion Egan ES, Jiang RHY, Moechtar MA, Barteneva NS, Weekes MP, Nobre LV, Gygi SP, Paulo JA, Frantzreb C, Tani Y, Takahashi J, Watanabe S, Goldberg J, Paul AS, Brugnara C, Root DE, Wiegand RC, Doench JG, Duraisingh MT Science, 348(6235), 711, 2015 |
| 7 |
In vivo discovery of immunotherapy targets in the tumour microenvironment Zhou PH, Shaffer DR, Arias DAA, Nakazaki Y, Pos W, Torres AJ, Cremasco V, Dougan SK, Cowley GS, Elpek K, Brogdon J, Lamb J, Turley SJ, Ploegh HL, Root DE, Love JC, Dranoff G, Hacohen N, Cantor H, Wucherpfennig KW Nature, 506(7486), 52, 2014 |
| 8 |
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelsen TS, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F Science, 343(6166), 84, 2014 |
| 9 |
The bromodomain protein Brd4 insulates chromatin from DNA damage signalling Floyd SR, Pacold ME, Huang QY, Clarke SM, Lam FC, Cannell IG, Bryson BD, Rameseder J, Lee MJ, Blake EJ, Fydrych A, Ho R, Greenberger BA, Chen GC, Maffa A, Del Rosario AM, Root DE, Carpenter AE, Hahn WC, Sabatini DM, Chen CC, White FM, Bradner JE, Yaffe MB Nature, 498(7453), 246, 2013 |
| 10 |
A melanocyte lineage program confers resistance to MAP kinase pathway inhibition Johannessen CM, Johnson LA, Piccioni F, Townes A, Frederick DT, Donahue MK, Narayan R, Flaherty KT, Wargo JA, Root DE, Garraway LA Nature, 504(7478), 138, 2013 |