Exposure of bagasse to 8 industrial preservatives such as sodium meta bisulphite (reducing agent), calcium hypochlorite and iodine (oxidizing agents) and Contaf-5E, Celphos, BU-30, liquid ammonia and quat-2C (broad spectrum fumigants/fungicides) was explored for its preservation at 200 kg scale for 6 months under ambient conditions, mimicking pulp and paper mill practices. Bacterial and fungal count, fiber and pith content, temperature, pH, reducing sugars (Soluble content) and brightness were monitored at monthly frequency to judge the efficacy of the above preservatives. Among them, only Celphos appeared to be superior to others, besides being cost-effective, eco-friendly and practical preservative oil the basis of parameters monitored. Its application is suggested until better preservative is identified.