In the present study, two spectrophotometric methods that do not require prior separation for simultaneous estimation of three drugs: paracetamol, nimesulide, and tizanidine in tablet formulation have been reported. Shimadzu UV-1700, capable of multi-component analysis was used for quantitation. Method I was based on derivative spectrophotometry and the absorbances were measured at 229.5, 271, and 323.0 nm, being the zero crossing points for paracetamol, nimesulide and tizanidine, respectively. Method 11 is based on multi-wavelength spectroscopic method, absorbances of standard solutions were measured at 229.0 nm, 272.0 nm, 262.0 nm and 323.0 nm based on statistical calculations and results of the sample solutions. All the three drugs obey Beer's law in the concentration range employed for the methods. The results of the analysis for both methods were tested and validated for various parameters according to International Conference on Harmonization Q 2B guidelines. The utility of the developed methods has been demonstrated by analysis of commercially available tablet dosage form.