As part of our ongoing research program on PVTx measurements using the isochoric and Burnett methods for hydrofluorocarbon + hydrocarbon and/or inorganic compound systems, this work reports on the experimental results for the difluorornethane (R32) + carbon dioxide (CO2) system obtained by the Burnett method. The apparatus was calibrated using helium, and its performance was confirmed by measurements for pure R32. The second and third virial coefficients were derived, and a good consistency was found after comparison with data in the literature. A new experimental procedure for mixture measurements was developed, on the basis of the gas chromatographic analysis of the sample collected during expansions. The gas chromatograph was calibrated precisely using samples prepared by the gravimetric method. PVTx measurements were performed for the binary R32 + CO2 system at T = (303, 313, 323, 333, and 343) K. The second and third cross virial coefficients were derived from the experimental results. No experimental data could be found in accessible literature sources on the PVTx for the R32 + CO2 system. Results were compared with the prediction obtained using REFPROP 6.01.