Volumetric and isobaric vapor-liquid equilibrium measurements are reported for 1,4-dioxane + 1-chlorobutane, + 2-chlorobutane, + 2-methyl-1-chloropropane, and + 2-chloro-2-methylpropane. From density measurements, excess volumes have been calculated and correlated with a Redlich-Kister equation. The VLE data are thermodynamically consistent and were well correlated with Margules, Van Laar, Wilson, NRTL, and UNIQUAC equations. The VLE results have been compared to the predictions by the UNIFAC and ASOG methods.