The enthalpy of solution of uracil, 5-fluorouracil, 5-chlorouracil, 6-chlorouracil, 5-bromouracil, 5-iodouracil, and 5-(trifluoromethyl)uracil in methanol at 298.15 K using the isoperibol solution calorimeter has been determined in the range of concentration (0.472 to 1.848) x 10(-3)/mol center dot kg(-1). The enthalpies of solvation were determined from the experimentally obtained enthalpies of solution and the previously determined enthalpies of sublimation for aqueous and methanol solutions. The transfer enthalpies of solution Delta(tr)H(m) for water-methanol, and the enthalpy of cavity formation Delta(cav)H(m) the enthalpy of solute-solvent interaction Delta(int)H(m) were calculated. The enthalpy of solvation Delta(solv)H(m) sublimation Delta(s)(g)H(m)(0), interaction Delta(int)H(m), and transfer Delta(tr)H(m) were correlated with the values of the surface-accessible areas of the compounds investigated.