The solubilities of 16 alpha,17 alpha-epoxyprogesterone in methanol, ethanol, acetone, ethyl acetate, acetic acid, and 1,4-dioxane were measured using an isothermal method from 283 K to 323 K. A laser monitoring observation technique was used to determine the dissolution of the solid phase in a solid + liquid mixture. The solubility of 16 alpha,17 alpha-epoxyprogesterone in the above solvents increased in the order methanol < ethanol < ethyl acetate < acetone < acetic acid < 1,4-dioxane.