The solubility of the sesquiterpene alcohol patchoulol in supercritical carbon dioxide was measured at pressures (P) ranging from 10.0 MPa to 25.0 MPa and temperatures (T) of 40.0 and 50.0 degrees C using a simple microsampling-type apparatus with a 100.5 mu L sample loop to remove aliquots for off-line analysis. The system was first validated using vanillin with off-line spectrophotometric analysis, then utilized for patchoulol measurements with off-line GC-MS analysis. The measured solubility of patchoulol in supercritical CO2 ranged from mole fractions of 0.43 x 10(-3) at 10.0 MPa and 50.0 degrees C to mole fractions of 9.4 x 10(-3) at 25.0 MPa and 40.0 degrees C.