The excess isentropic compressibilities are computed by measuring the density and speed of sound of binary mixtures of N-methylacetamide with ethyl acetate, ethyl chloroacetate, and ethyl cyanoacetate over the entire range of volume fraction in the temperature range of (303.15 to 318.15) K. The experimental results are fitted to a Redlich-Kister type polynomial equation. Estimated coefficients and standard deviation values are also presented.