Isothermal vapor-liquid equilibria (VLE) and excess molar enthalpies (H-E) for the binary systems of dimethyl ether (DME) with n-decane, n-dodecane, 1-octene, 1-decene, benzene, toluene, and water were measured at 323.15 K with a computer-driven static apparatus and an isothermal flow calorimeter, respectively. None of the measured binary systems show azeotropic behavior at this temperature. The system DME + water shows a miscibility gap. The experimental VLE and H-E data were correlated with different G(E) models and the Redlich-Kister polynomial.