Experimental solubilities of cyclotrimethylenetrinitramine (RDX) in binary solvent mixtures, such as gamma-butyrolactone + water, cyclohexanone + water, N-methyl pyrrolidone + water, and acetone + water, were measured over the temperature range of 273.15 K to 363.15 K. The enthalpy of dissolution was determined experimentally from the solubility data.