As one of the most regularly traded-in medicines in the world, acetylsalicylic acid has been scarcely researched when in solution. This study is aimed at determining the solubility of acetylsalicylic acid in ethanol, acetone, propylene glycol, and 2-propanol, in addition to comparing their solubility values with the expected from an ideal solution. The solubility of acetylsalicylic acid is highest in acetone in all studied temperature ranges until T/K = 326.3. Propylene glycol presents lower solubility data in all studied temperature ranges. The solvent that presented the lowest average percent logarithmic deviation, concerning the ideality of the system, was ethanol, and the highest value of average percent logarithmic deviation was found in propylene glycol solutions. The experimental solubility data were correlated with the Nyvlt model. We conclude that the Nyvlt model is' capable of representing properly the experimental data.