Vapor-liquid equilibrium (VLE) data were measured using a static total pressure apparatus for binary pairs of 2-methylpropane (isobutane) + methanol, + 2-propanol, + 2-butanol, and + 2-methyl-2-propanol (TBA) at 364.51 K. The measured T, p, z data were fitted with Legendre polynomials and reduced by using the method of Barker to obtain the phase equilibrium data. In addition to Legendre polynomials, Wilson binary interaction parameters for the activity coefficient model were regressed. Azeotropic behavior was observed for the binary 2-methylpropane (1) + methanol (x(1) = 0.871, p = 1822 kPa).