Using a laser monitoring observation technique, the solubilities of benzoic acid, p-methylbenzoic acid, m-methylbenzoic acid, o-methylbenzoic acid, p-hydroxybenzoic acid, and o-nitrobenzoic acid in 1-octanol were measured by the polythermal method in the temperature range of (293.15 to 323.15) K. The experimental data were regressed with the Wilson equation and the lambda H equation. The experimental results showed that the solubility of the six chemicals in 1-octanol increased significantly with temperature. The results indicate that the molecular structure and interactions affect the solubility significantly. Both the Wilson equation and the lambda H equation correlate the experimental data well.