Using a laser monitoring observation technique, the solubilities of 11 beta-hydroxypregna- 1,4,16-triene-3,20-dione in ethanol, acetone, and ethanol + water were determined by the synthetic method. The experimental data can be well correlated by the Apelblat equation (for the ethanol and acetone pure solvent system) or the (CNIBS)/Redlich-Kister equation (for the binary ethanol + water solvent mixtures system).