The density, viscosity, refractive index, surface tension and ultrasonic velocity have been determined for 4-hydroxy 4-methyl pentanone with nitrobenzene or ethyl benzene over the entire composition range at temperatures of (303.15, 313.15, and 323.15) K. The viscosity values were fit to the models of Grundberg and Nissan, Hind, and McAllister. The thermophysical properties under study were fit to the Jouyban-Acree model. In addition, artificial neural networks were used to simulate all the thermophysical properties of liquid mixtures with mole fraction at (303.15, 313.15, and 323.15) K. The excess values were correlated using the Redlich-Kister polynomial equation to obtain their coefficients and standard deviations.