Experimental solubilities are reported for anthracene dissolved in quaternary solvent mixtures of 2,2,4-trimethylpentane + 2-propanone + methanol + ethanol, 2,2,4-trimethylpentane + 2-propanone + methanol + I-propanol, and 2,2,4-trimethylpentane + 2-propanone + methanol + 2-propanol at 298.15 K. Twenty compositions are studied for each of the three quaternary solvent systems. Results of these measurements were used to evaluate the prediction capability of previously developed quantitative structure-property relationships employing the solubility data in monosolvents, and the overall mean deviation (OMD) of the models varied between (10.3 to 18.6) %. Using fully predictive methods, the OMDs varied between (20.2 and 21.1) %.