The solubility of valsartan in ethyl acetate + hexane binary mixtures was measured by a synthetic method over the temperature range from (278.15 to 313.15) K at atmosphere pressure. The results show that the solubility of valsartan increases with increasing temperature and the increasing mole fraction of ethyl acetate of the binary mixtures. The experimental data were correlated using the modified Apelblat model, and the agreement with the experimental data was very good.