Journal of Chemical and Engineering Data, Vol.54, No.5, 1592-1597, 2009
Experimental and Theoretical Investigation of the Phase Behavior of Naproxen in Supercritical CO(2)
New experimental solubility data of Naproxen in supercritical CO(2) for (313 to 353) K and pressures ranging from (15 to 40) MPa are presented. This covers the range where processes with supercritical fluids such as Rapid Expansion from Supercritical Fluids are typically performed. In addition, the solid-liquid-gas equilibrium line for the CO(2) + Naproxen system was determined from (0.1 to 30) MPa. The solubility data are correlated by three different methods: two methods for the density-solubility correlation and one method for the pressure-solubility correlation. Different literature data and predictions of the sublimation pressure of Naproxen, which are required for the solubility correlation, are compared.