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Journal of Chemical and Engineering Data, Vol.54, No.5, 1643-1646, 2009
Volumetric and Viscometric Studies of Salicyl Amide, Salicylic Acid, and Acetyl Salicylic Acid in Alcohols at Different Temperatures
Nonsteroidal anti-inflammatory drugs (NSAIDs) exhibit analgesic, anti-inflammatory, antipyretic and platelet inhibitory properties. Density and viscosity of salicyl amide, salicylic acid, and acetyl salicylic acid in water, methanol, and ethanol at T = (293.15 to 313.15) K have been measured in a molality range of (9.7 . 10(-3) to 32.5 . 10(-3)) mol . kg(-1) with the help of a commercially available vibrating-tube densimeter and viscometer. From the density data, apparent molar volume (V(phi.1)), partial molar volume (V(m)(infinity)), thermal expansion coefficient (alpha(infinity)(2)), and (partial derivative(2)V(m)(infinity)/partial derivative T(2)) are calculated. The viscosity data are analyzed by the Jones-Dole equation to determine the values of the viscosity B-coefficient.