Dimethyl ether (DME) is a clean and economical alternative fuel. In addition, it is also an ozone-friendly refrigerant. Burnett measurements were carried out at temperatures from (344 to 393) K and at pressures from (0.055 to 4.015) MPa. A total of 138 experimental points, taken along 15 isotherms and 12 different temperatures, were obtained. The apparatus was calibrated by helium. The derived second coefficients were compared with the selected correlations and with literature data.