The solubility of indinavir sulfate in ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-methyl-1-propanol was measured over the temperature range of (278.35 to 314.15) K under atmospheric pressure. The experimental data were correlated by the modified Apelblat model. The results show that the solubility of indinavir sulfate in the selected solvents increased with increasing temperature.