Isothermal vapor-liquid equilibrium (VLE) data at 333.15 K are measured for the binary systems {di-isopropyl ether (DIPE) + ethanol} and {DIPE + 2,2,4-trimethylpentane} and for the ternary system {DIPE + ethanol + 2,2,4-trimethylpentane} by using headspace gas chromatography. The experimental VLE data were correlated with the G(E) model: Margules, van Laar, Wilson, nonrandom two-liquid, and UNIQUAC equations. The excess molar volume and deviations in molar refractivity data are reported for the binary systems {DIPE + ethanol}, {DIPE + 2,2,4-trimethylpentane}, and {ethanol + 2,2,4-trimethylpentane} at 303.15 K. In addition, excess molar enthalpies for two binaries, {DIPE + ethanol} and {DIPE + 2,2,4-trimethylpentane}, at 303.15 K are also reported. These data were correlated with the Redlich-Kister equation. The excess molar volume and deviations in molar refractivity data are also reported for the ternary system {DIPE + ethanol + 2,2,4-trimethylpentane} at 303.15 K. The ternary data were con-elated with the Cibulka equation. Also, the isocline of excess molar enthalpies for the same ternary system at 303.15 K was calculated using the Radojkovic equation.