Excess molar enthalpies for the binary and ternary mixtures of cyclohexane, tetrahydropyran, and piperidine have been measured using a Calvet microcalorimeter at 308.15 K and atmospheric pressure. All of the binary and tertiary systems show endothermic behavior. The experimental binary results are correlated using the Redlich-Kister equation. The excess molar enthalpies for the tertiary mixture are correlated using the Cibulka equation. The capability of an artificial neural network algorithm to model these data is finally studied.