The solubility of physalin D in ethanol, methanol, propanone, trichloromethane, ethyl ethanoate, and water at temperatures from (283.2 to 313.2) K was measured under at a pressure of 0.1 MPa. The solubility of physalin D in these solvents increases with increasing temperature. The experimental solubility data were correlated with the Apelblat equation.