The solubility of sulpiride in organic solvents of acetone, N-methylpyrrolidone (NMP), ethanol, tetrahydropyran (THF), N,N-dimethylformamide (DMF), and methanol between (278 and 328) K was measured using a laser monitoring observation technique. Results of these measurements were correlated with a semiempirical equation. For the seven solvents studied, the data are fitted well with a semiempirical equation.