The enthalpies of dilution of N,N'-hexamethylenebisacetamide in aqueous glucose and sucrose solutions have been measured by using a mixing-flow microcalorimeter at 298.15 K. The enthalpic interaction coefficients (h(2), h(3), h(4)) in the range of the saccharide mobility, (0 to 2.0) mol.kg(-1), have been calculated according to the McMillan-Mayer model. The results show that the enthalpic pairwise interaction coefficients h(2) of N,N'-hexamethylenebisacetamide in both the saccharide solutions arc positive and become less positive with the increase of the saccharide modality. The value of h(2) in aqueous glucose solutions is larger than that in aqueous sucrose solutions of the same molality. The effects of the two saccharides on h(2) are discussed in terms of the solute solute and solute solvent interactions.