The solubilities of decabromodiphenyl ether (DeBDE) in propanone, ethyl acetate, 1-methyl-4-(1-methylethenyl)cyclohexene, methylbenzene, and tetrahydrofuran were measured in the temperature range of (283.0 to 323.0) K by high-performance liquid chromatography (HPLC). The modified Apelblat equation was used to correlate the relationship between solubility and temperature. The correlated data showed a good agreement with the experimental results. These data of solubility can be used in the optimized separation of decabromodiphenyl ether.