The anthracene solubility in methanol, ethanol, 1-propanol, and 2-propanol from (298.2 to 333.2 K) and also in binary solvent mixtures of 2-propanone + C-1-C-3 alcohols at 298.2 K was reported. The van't Hoff equation was used for correlation of the solubility data in monosolvents at different temperatures. The solubility of anthracene in mixed solvents was predicted using previously developed quantitative structure property relationships (QSPR) that required knowledge of the solubility data in monosolvents. The overall mean percentage deviation of the correlated solubilities in monosolvents at different temperatures was 4.8 To. The corresponding value for solubility prediction methods in solvent mixtures varied from (8.5 to 11.9) %. Using ab initio prediction methods, the overall mean percentage deviations varied from (14.7 to 15.8) %.