A static-type phase equilibrium apparatus was installed to measure isothermal vapor-liquid equilibrium (VLE) data of polyoxyethylene 4-octylphenyl ether (POEOPE), commonly known as polyethylene glycol mono-4-octylphenyl ether, with methanol at (341.0 to 403.1) K, POEOPE + ethanol at (342.6 to 454.1) K, and POEOPE + propan-2-ol at (350.1 to 453.3) K. With a given feed composition, equilibrium pressures were measured at constant temperatures to obtain p-T-x data. The experimental data were correlated with the Antoine equation. Those VLE data were also correlated with the universal quasichemical (UNIQUAC) and the nonrandom two-liquid (NRTL) activity coefficient models, respectively. The correlation results showed good agreement between the calculated values and the experimental data. The solvent activities calculated from the NRTL model are generally consistent with the values evaluated from the smoothed experimental results.