In this study the effect of adsorption parameters such as pH, concentration of uranium(VI), shaking time, and temperature on methyl 3-O-acetyl-5,6-dideoxy-(S)-1,2-trichloroethylidene-alpha-D-xylo-hept-5(E)-eno-1,4-furano-uronate (MOADDTCEXHEFU) for U(VI) ions have been investigated. The adsorption data for uranium(VI) were well-fitted by the Langmuir isotherm. Thermodynamic analysis showed that the value of Delta G degrees is negative and Delta H degrees and Delta S degrees are positive. These results and a Fourier transform infrared (FTIR) spectrum analysis show that uranium (VI) ions were successfully bonded to this molecule. The affinity of MOADDTCEXHEFU to Th(4+), Ba(2+), and also Mg(2+) is about 10 times higher than uranium(VI).