The solubilities of 16-dehydropregnenolone acetate in methanol, ethanol, cyclohexane, acetone, and ethyl acetate have been measured from (278.55 to 340.35) K at atmospheric pressure using the synthetic method. The solubilities were determined by a laser monitoring observation technique. The experimental data were correlated with the modified Apelblat equation with the relative deviation less than +/- 4.45 %.