The solubility of mesquite gum (MG) in supercritical carbon dioxide (SC-CO(2)) was determined for the first time at T = (313, 323, 333, and 343) K and with pressures ranging from (138 to 345) bar. The solubility values of MG in SC-CO(2) in mole fraction railed from 2.622.10(-9) to 4.189.10(-9), 2.768.10(-9) to 6.365.10(-9), 3.442.10(-9) to 7.570.10(-9), and 4.194.10(-9) to 11.886.10(-9) at (313, 323, 333, and 343) K, respectively. This biomaterial showed low solubility in SC-CO(2) based on the MG molecule polarity and high molecular weight. The experimental solubility data were successfully correlated with the Bartle and Mendez-Santiago and Teja models. Using correlation results, the MG enthalpy of sublimation was Delta H(sub) = 57.63 kJ.mol(-1).