The NRTL activity model parameters were determined for the following binary systems: 2-ethoxyethanol + 2-ethoxyethyl acetate, 2-ethoxyethanol + 2-butoxyethanol, 2-ethoxyethanol + 2-butoxyethyl acetate, 2-ethoxyethyl acetate + 2-butoxyethanol, 2-ethoxyethyl acetate + 2-butoxyethyl acetate, and 2-buthoxyethanol + 2-butoxyethyl acetate. For the estimate of NRTL activity model parameters, measurements of the bubble point of binary mixtures of a known composition were made at atmospheric pressure from (93 to 101.3) kPa. Ideal behavior was considered for the vapor phase. It was assumed that no reaction occurs between the acetates and alcohols of the binary mixtures.