Experimental hydrate dissociation pressures for the hydrogen sulfide + neohexane (2,2-dimethylbutane) + water and methane + neohexane + water systems are reported in the temperature ranges of (287.2 to 293.2) K and (275.5 to 286.8) K, respectively. The experimental data were generated using an isochoric pressure-search method. The hydrate dissociation data for the methane + neohexane + water system are compared with some selected experimental data from the literature, and the acceptable agreement confirms the reliability of the experimental method used in this work The experimental data for both measured systems are finally compared with the corresponding experimental data in the absence of neohexane reported in the literature to study the hydrate promotion effects of neohexane.