Studies of wavy stratified and stratified/atomization two-phase flow in horizontal pipes are outlined. Notable features of this flow regime include the appearance of disturbance waves, the atomization onset and the drastic change of the gas/liquid interface profile from flat to "concave. "Liquid-to-wall shear stress tends to decrease circumferentially. A computational procedure for predicting main flow characteristics, which takes into account the above results in its design relations, is first assessed with detailed experimental data and is then combined with a CFD code, aiming at enhancing the predictive capability.