For the first time, the manufacturing of metal-organic framework-based monoliths using a two-step process is reported. In a first experiment, the in situ synthesis of Cu(3)(BTC)(2) (benzene tricarboxylate [BTC]) on cordierite monoliths was chosen to immobilize Cu(3)(BTC)(2). As this approach turned out to be of major disadvantages, the manufacturing of Cu(3)(BTC)(2) monolithic structures was chosen. The two-step fabrication process included the manufacturing of a molding batch in a lab-scale kneader followed by extrusion in a ram-extruder. As additives, methyl hydroxyl propyl cellulose and methoxy functionalized siloxane ether were chosen. The resulting monolithic structures have a specific inner surface area of 370 m2/g and show a high mechanical stability of 320 N.