The use of vibration on a filter can effectively reduce the membrane fouling by the shearing action on the membrane surface. The effect of vibration parameters on crossflow microfiltration performance was studied with two kinds of particle suspensions. The experimental results show that the filtration rate depends mainly on the product of frequency and amplitude. A method of calculating the crossflow microfiltration process with vibration was developed by incorporating the effects of vibration parameters into a particle adhesion probability model. The calculated results coincide favorably with the experimental results for a polystyrene latex suspension.