An optimization method for numerical simulation of CO2 adsorption systems was studied. The optimization target is an adsorption system of CO2 contained in exhaust gas from a power plant by use of rotor towers filled with honeycomb type zeolite. The fully optimized conditions were obtained by sequentially repeating optimization for nine parameters until all parameters reached steady states. The optimal operation conditions for the actual plant (flow rate of exhaust gas: 70000 m(3)(STP) . h(-1)) were obtained from our simulations. As a typical example, the following optimal operation conditions were obtained for a boundary CO2 recovery rate of more than 60%, CO2 concentration of more than 90% and minimum power consumption energy. (1) The power consumption energy including blower energy was 899 KJ. (2) CO2 recovery rate was 60.1%. (3) CO2 concentration was 92.4%. It was also found that the power consumption energy can be reduced further if the system is slightly changed or the target recovery rate and the concentration are slightly decreased.