Enantioselective enrichment of racemic oxprenolol dissolved in a hexane-2-propanol mixture was achieved with a solid chiral polymer membrane consisting of cellulose tris(3,5-di-methylphenylcarbamate) coated on a Teflon membrane filter. The oxprenolol obtained through the membrane was rich in (S)-isomer up to about 50% ee at initial stage and (R) -enrichment of a source phase (23% ee) was achieved.