The search for new ecologically pure production processes for numerous cellulose derivatives is important technologically. It is well known that under shear deformation in solid substances, various physical and chemical effects may take place. The possibility of production of some cellulose derivatives, such as carboxymethylcellulose and cellulose acetates, is shown under conditions of joint action of high pressure and shear deformation at room temperature. The formation of an easily hydrolyzed fraction of cellulose under these conditions is also investigated. This reaction procedure is of great practical interest, as it makes it possible to reduce the consumption of reagents and to carry out the process in the absent of solvents.