The whole blood viscosity (WBV) is one of the major independent indicators for the risk of cardiovascular disease, stroke, and peripheral arterial diseases. Furthermore, oxidized LDL molecules are known to cause atherosclerotic plaques in arteries, and it is one of the key components that increase WBV. The present study attempted to reduce WBV by coagulating plasma proteins and lipid molecules from blood plasma using non-thermal dielectric barrier discharge (DBD) and removing them through filtration. The DBD treatment was found to produce coagulated particles in blood plasma. After filtration of the coagulated particles, WBV decreased by 9.1 and 17.7% for both systolic and diastolic blood viscosities, respectively. The present results suggest that the removal of excess plasma proteins and lipid molecules might be feasible using DBD treatment.