The catalytic properties of metal disilicides TiSi(2), VSi(2), MoSi(2), HfSi(2), TaSi(2), and WSi(2) in the reaction of liquid-phase oxidation of octene-1 with molecular oxygen and the kinetic features of this process in the presence of the most active disilicide VSi(2) were studied. It was shown that the disilicides had an effect on the oxidation process only in the presence of hydroperoxide. It was found that the rate of oxidation on VSi(2) increased owing the enhancement of the radical generation reaction via the bimolecular degradation of the hydroperoxide. A kinetic scheme was proposed which adequately describes the process, and the kinetic parameters of the process were calculated.