Pneumatic conveying of powdered and granular materials is a very common transport technology across a broad range of industries, for example, chemicals, cosmetics, pharmaceuticals, and power generation. As the demands of these industries for greater efficiency increases and to comply with environmental regulations there is a need for a more fundamental understanding of the behavior of materials in pneumatic conveying systems. The approach presented in this article is to develop a model of a section of pneumatic conveying line, a horizontal or vertical 90 degrees bend, in the commercial CFD software package FLUENT and to describe the multiphase flow behavior by the mixture or Eulerian method. Models of this type have been used in the past to show qualitative and quantitative agreement between model and experiment. The model results presented were compared with experimental data gathered from an industrial-scale pneumatic conveying test system. Broad qualitative agreement in trends and flow patterns were found. Quantitative comparisons were less uniform, with predictions from around 10% to 90% different from experimental results, depending on conveying conditions and bend orientation.