The effect of polyamide end-group configuration on morphology generation and toughness of blends with maleated elastomers was investigated. Two difunctional polyamides, a copolymer containing 15% nylon 6,6 and an amine enriched nylon 6, were compared to monofunctional nylon 6 materials of equivalent molecular weight and melt viscosity. Difunctional polyamides have some chains with amine groups on both ends capable of reacting with the maleated rubber phase resulting in crosslinking-type effects. The elastomers used included styrene-butadiene-styrene block copolymers with a hydrogenated midblock, SEES, and versions with X% grafted maleic anhydride, SEBS-g-MA-X%, and a maleated ethylene/propylene random copolymer, EPR-g-MA. Blends based on difunctional polyamides form large, complex rubber particles when compounded in a single-screw extruder; however, by compounding with an appropriate twin-screw extruder, the size and complexity of the particles can be reduced to levels similar to blends with the monofunctional nylon 6 controls. Measurement of the extent of reaction between the amine end groups and the grafted maleic anhydride revealed that a larger number of amine groups are consumed for the difunctional polyamides than for their monofunctional controls. The room-temperature Izod impact strength of blends with the difunctional polyamides is greater than are the corresponding blends with the controls; however, subambient toughness depends mainly on the inherent ductility of the polyamide matrix.