The aim of the current work is to explicitly link the inherent safety principles of minimization, substitution, moderation and simplification with strategies for dust explosion prevention and mitigation. A brief review of inherent safety and its basic principles is first given. This is followed by a discussion of various ways in which the dust explosion hazard can be minimized, substituted, moderated and simplified. Particular attention is paid to the relationship between each inherent safety principle and (i) various dust explosibility parameters, (ii) alternate methods of processing, (iii) selection of process equipment, and (iv) development and implementation of safe-work procedures. Original research results are presented, along with industrial case studies and previously published results that have been reinterpreted in terms of inherent safety and its basic principles. It is anticipated that this research will be of value to industry as a complement to the relatively well-established suite of engineered and procedural dust explosion risk reduction measures. (C) 2008 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved.