Multiuse pilot-scale plants often run production campaigns in parallel, requiring frequent changes in the chemistry from campaign to campaign and modified procedures to match the new production needs within a short time span. Facilities must also match clients' product chemistry and process demands with their equipment capabilities. These campaigns may occur several times a year with considerable overlap of projects. Several basic but important questions arise for the facility manager. For example, bow do the facilities' personnel pay adequate attention to all of the safety issues associated with the chemical reactivity? ensure that a facility's equipment and the new process chemistry fit together safely, especially with respect to chemical reactivity? verify emergency relief and vent sizing, estimate cooling duty needs, and implement the necessary process safety changes? This paper introduces a new approach and procedure that assists plant personnel to assess the process and identify the potential hazards. The procedure also recommends a methodology to evaluate the nature and extent of the hazard. (c) 2006 American Institute of Chemical Engineers Process.