This report provides guidance on the type of equipment that is necessary to ensure inerting when processing flammable liquids, combustible dusts, or hybrid mixtures. It will explain in depth the technical requirements for the implementation of this preventive measure and the limitations. It will assist people in plants with operations that need to be protected by inerting. It reflects the present state of the art and current knowledge of the assessment and requirements associated with inerting. (C) 2006 American Institute of Chemical Engineers.