This article examines the challenges of defining a global mechanical integrity (MI) program for a chemical company with manufacturing facilities in North America, South America, Europe, and Asia. The article examines the differing regulatory requirements and engineering standards, and also investigates the challenges associated with limited technical resources and limited availability of state of the art non-destructive examination methods in various regions. This article further discusses the cultural views of All in various global areas. The primary benefit of a global MI program is safer plants. Failures in MI programs have led to catastrophic failures. Plant equipment must always operate safely. Vessels and piping systems must maintain containment of hazardous chemicals, and energy and safety equipment such as relief devices and critical instrument must function when needed. This article describes the details of an effective international MI Program. (C) 2009 American Institute of Chemical Engineers Process Saf Prog 29: 47-50, 2010