The enthalpies of solution of 2,4,6-trinitro-1,3,5-trihydroxybenzene (trinitrophloroglucinol, TNPG) in N, N-dimethylformamide (DMF) and EtOH are determined. The thermodynamics of these processes are also studied. The experiments are carried out by a SETARAM C80 calorimeter at 298.15 K. The empirical formulas for enthalpies of solution of TNPG in both DMF and EtOH are calculated by polynomial expressions. The resulting formulas are: Delta(sol)H = -97.23375 + 1646.78192b(1/2) - 6903.38866b (in DMF), and Delta(sol)H = 93.19133 - 1731.03621b(1/2) + 8016.6928b (in EtOH). Also covered are the relative apparent molar enthalpies of solution (Phi L(i)) and the relative partial molar enthalpies (L(i)), respectively. The kinetics formulas are y = -6.2148 + 0.7014x (in DMF), and y = -6.3678 + 0.5766x (in EtOH).